RhCG is the major putative ammonia transporter expressed in the human kidney, and RhBG is not expressed at detectable levels
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چکیده
منابع مشابه
RhCG is the major putative ammonia transporter expressed in the human kidney, and RhBG is not expressed at detectable levels
Rhesus glycoprotein homologs RhAG, RhBG, and RhCG comprise a recently identified branch of the Mep/Amt ammonia transporter family. Animal studies have shown that RhBG and RhCG are present in the kidney distal tubules. Studies in mouse and rat tissue suggest a basolateral localization for RhBG in cells of the distal tubules including the alpha-intercalated cells (alpha-IC), but no localization o...
متن کاملRhBG and RhCG, the putative ammonia transporters, are expressed in the same cells in the distal nephron.
Two nonerythroid homologs of the blood group Rh proteins, RhCG and RhBG, which share homologies with specific ammonia transporters in primitive organisms and plants, could represent members of a new family of proteins involved in ammonia transport in the mammalian kidney. Consistent with this hypothesis, the expression of RhCG was recently reported at the apical pole of all connecting tubule (C...
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متن کاملLocalization of the ammonium transporter proteins RhBG and RhCG in mouse kidney.
Ammonia is both produced and transported by renal epithelial cells, and it regulates renal ion transport. Recent studies have identified a family of putative ammonium transporters; mRNA for two members of this family, Rh B-glycoprotein (RhBG) and Rh C-glycoprotein (RhCG), is expressed in the kidney. The purpose of this study was to determine the cellular location of RhBG and RhCG protein in the...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Renal Physiology
سال: 2009
ISSN: 1931-857X,1522-1466
DOI: 10.1152/ajprenal.00013.2009